INAOE | Optics | Laboratories | Biomedical Optics

Biomedical Optics

The Biomedical Optics Lab (BOL) began its activities in 2006, when the Optic’s Coordination determined that its strategic field would be Biophotonics.
Members of this research group are: 

Jorge Castro Ramos Ph.D.  (in charge of the group)


Project’s strategic objective:

To carry out theoretical and experimental research on optic radiation and biological tissue interaction, including the study of ex-vivo human tissue samples and in-vivo research in patients, in order to determine diagnostic methodologies and new therapies based on laser use and optic radiation in general.

Project Justification:

Many countries objectives, Mexico in particular, include searching for solutions to countless health problems, this is why the Biomedical Optics area is a priority area within the Institute of Astrophysics, Optics and Electronics. In this area, which includes Medical Optics, the strategic objective is to collaborate in solving health problems within Mexican society.

This project’s strategic objective is to search for solutions to the population’s health problems. Additionally, this project will promote INAOE integration with other higher education institutions and with non-governmental institutions, since the project will be developed with the Autonomous University of Puebla, University Hospital, the National Neurology and Neurosurgery Institute: “Manuel Velazco Suárez” and the Center for Cancer Studies and Prevention (CEPREC).

We will also promote Doctor and Masters in Science training which will strengthen the academic bodies of Public Research Centers and Higher Learning Institutions, these human resources will then become professors in high level universities, clinics and hospitals, this will aid in our search to improve the quality of life in Mexico’s population. Of course the results of this project’s research will be transferred to civil and governmental societies, and in some cases, to companies that will manufacture and commercialize instruments and equipment that resulted from this research.

The diagnosis and treatment of lesions through the implementation of optic methods is currently a research field in development. Mainly, with an emphasis on the study of human tissue optic properties, with hopes to optimize these methods. The project’s objective is to encourage basic and theoretical research with regard to interaction between optic radiation and biological tissues, including studies with human tissue “ex-vivo” samples and “in-vivo” research with patients.

Special attention will be paid to spectroscopy phenomenon of diffuse reflection and tissues’ auto-fluorescence in the near UVA-visible-IR range of the electromagnetic spectrum. Both phenomena will be studied using modern optic equipment for the acquisition and registry of optic spectrums as well as in the acquisition and processing of infrared and fluorescent images. Additionally, participating hospitals will carry out traditional studies in patients in order to establish correlations and confidence levels in the results of this research.

Problems to be solved:

This project will solve public health issues, particularly in skin and cervical-uterine cancer detection and in the evaluation of bilirubin levels in newborns. Today, these public health issues are solved with invasive techniques that have a long diagnostic period due to the fact that most of them require a pathological study of skin tissues. This type of testing is not only invasive, in many cases it causes pain and bleeding. There is also the risk of mixing up patient’s samples, which has been reported, this is due to the amount of studies that are performed, this leads to a miss diagnosis that, in best of cases, causes the study to be redone.

In addition, in current diagnostic procedures it is not possible to detect cancer cells in the early stages of the disease. Due to this, in our project we plan to design methodologies that would allow diagnosis through non invasive in-vivo measurements, -without any side effects-, that permit an immediate diagnosis and more importantly, allow the detection of abnormal cells in a stage at which treatment is highly effective.

Alternative Solution :

Analysis of light interaction with biological tissues is an alternative to abnormal tissue diagnosis. The necessary tools to carry out this diagnosis are: diffuse reflection spectroscopy and auto-fluorescent spectroscopy, they provide information through the study of reflected light for studied tissues, based on the light used to illuminate these samples. Using spectroscopy in the ultraviolet near-infrared band we can distinguish healthy cells from sick cells allowing the diagnosis and detection of cancer cells. Also, different blood levels correspond to different light spectrums, allowing the evaluation of bilirubin levels. Due to the fact that biological tissues present fluorescence phenomena, it is said that they are fluorescent and they do this differently in healthy cells than when there are cancer cells present. This permits the diagnosis of cervical-uterine cancer, skin cancer tissues and abnormal bilirubin levels, etc.

In all cases mentioned above, we plan to develop instrumentation and the necessary equipment, as well as diagnostic algorithms and methodologies and to propose an alternative diagnosis for abnormal tissues.

Currently, commercial equipment is available for this type of measuring: spectographers, spectrometers, etc. however, they are not designed expressly for this type of applications, so the project will consider using the benefits provided by acquired equipment. Through the ideas and developments carried out until now in this field, we plan to obtain a functional prototype with a software of its own. Acquired commercial equipment will allow the development of a new product, with a greater added value and with the advantage of having this new instrument’s full know how. Due to this, the acquisition of requested equipment for this project is fundamental in completing it successfully.

Project Goals:

1. Establish optic models of interaction between optic radiation and biological tissues.
2. Establish a technique for measuring neonatal bilirubin levels.
3. Design a methodology for diagnosing cervical-uterine cancer.
4. Design an image calibration method for different cameras and monitors.

Project Impact:

1. Human resource training at a doctorate level.
2. Integration of the INAOE and the Autonomous University of Puebla (BUAP) through the University Hospital.
3. Transfer results from University Hospital research.
4. Link civil societies with companies such as CEPREC, and transfer results from our research.

Last Update:
26-02-2013 a las 13:07 by

Address: Luis Enrique Erro # 1, Tonantzintla, Puebla, Mexico | Tel: (222) 247.29.40 | Contact: | Fax: 247.29.40


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